The human genome is contained within a vast jumble of DNA. Its 20,000 or so genes are concealed within strings of As, Ts, Gs, and Cs, and each gene must be turned on at the right time and in the right cells. For the first time, scientists have glimpsed the cellular machinery that accomplishes that feat, as it assembles directly on the DNA and readies it for transcription into RNA, the first step in protein production.