Cancer

04/22/2014 - 16:33

Potentially valuable drugs slowed down by sticky molecules may get another shot at success. Joint research by the National Institute of Standards and Technology (NIST), Genentech, the University of Delaware and Institut Laue-Langevin (ILL) has revealed the reason why a certain class of proteins tends to form clusters that lead to high viscosity in drug solutions.

04/21/2014 - 11:40

Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a molecule, or biomarker, called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of cancer cells.

04/18/2014 - 09:09

A new gene variant present in about one third of people appears to significantly increase the risk of colorectal cancer associated with eating processed meat. The study of over 9000 colorectal cancer patients compared with over 9000 control subjects suggests that a genetic variant called rs4143094 is significantly associated with processed meat consumption. These are the main findings of a study published on 17th April 2014 in the journal PLoS Genetics. The study is from a multinational team of collaborating laboratories.

 

04/16/2014 - 08:43

A new blood test designed to detect hypermethylation of ten key breast cancer genes accurately detects advanced breast cancer. It has great potential as a method to detect recurrence in asymptomatic patients and monitor treatment response. These are the findings of a study led by researchers in Johns Hopkins Kimmel Cancer Center published on 15th April in the journal Cancer Research.

 

04/15/2014 - 16:00

A chimeric mouse model called TK-NOG which has a humanized liver would have predicted liver toxicity that developed in humans during the 1993 clinical trial of fialuridine. That is the major finding of a new study from researchers in Stanford University, the Center for the Advancement of Health and Biosciences and the Ely Lilly Department of Drug Disposition, all in California. The study is published on 15th April 2014 in the journal PLoS Medicine.