Cell Biology

04/22/2014 - 16:17

Despite decades of common use for surgeries of all kinds, the precise mechanism through which general anesthesia works on the body remains a mystery. This may come as a surprise to the millions of Americans who receive inhaled general anesthesia each year. New research led by the Perelman School of Medicine at the University of Pennsylvania investigated the common anesthetic sevoflurane and found that it binds at multiple key cell membrane protein locations that may contribute to the induction of the anesthetic response.

 

04/11/2014 - 09:34

The cancer protein KRas is a factor in the development of several types of cancer. Mutated KRas, for example, can be found in a large number of all tumour cells in patients with pancreatic cancer. It sits on the inner leaflet of the cell membrane and relays signals into the cell’s interior. Scientists at the Max Planck Institute of Molecular Physiology in Dortmund have now discovered why KRas is almost exclusively found at the cell membrane when observed under the microscope.

 

04/03/2014 - 12:35

Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including proliferation.

 

04/02/2014 - 21:39

Cell culture studies suggest that vitamin A derivatives can reverse pre-malignant lesions to normality, but only has a small window of opportunity as it has no impact on invasive or tumorigenic stage cells. These are the findings of a new study from researchers in Thomas Jefferson University in Philadelphia and the University of Chicago, published early online in the International Journal of Oncology.

 

04/01/2014 - 09:33

Scientists now present a protein that facilitates the control of nerve cells by light. It might be used as a basis of studies of diseases of the nervous system. The ChlocC channelrhodopsin presented now reacts about 10,000 times more sensitively to light than other proteins used so far for switching off nerve cells.

 

03/17/2014 - 10:00

A team of biologists and engineers at the University of California, San Diego has discovered that white blood cells, which repair damaged tissue as part of the body's immune response, move to inflamed sites by walking in a stepwise manner. The cells periodically form and break adhesions mainly under two "feet," and generate the traction forces that propel them forward by the coordinated action of contractile proteins. Their discovery, published March 17 in the Journal of Cell Biology, is an important advance toward developing new pharmacological strategies to treat chronic inflammatory diseases such as arthritis, irritable bowel syndrome, Type 1 diabetes, and multiple sclerosis.