Amyotrophic Lateral Sclerosis

01/16/2014 - 13:16

At the heart of brain diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At present, there is no known way to reverse protein misfolding.


12/03/2013 - 10:21

Research led by King’s College London has identified a new genetic variant, located on chromosome 17, associated with sporadic amyotrophic lateral sclerosis (ALS) – the most common form of motor neurone disease (MND). With genetic data from over 17,000 individuals, the study is the largest of its kind and provides a new insight into the genetic structure of the disease.


03/23/2013 - 08:55

Results from a clinical trial into amyotrophic lateral sclerosis (ALS), led by King’s College London’s Institute of Psychiatry show that lithium carbonate is ineffective at treating the disease.

01/15/2013 - 15:23

Western researchers have identified a new genetic mutation for amyotrophic lateral sclerosis (ALS), opening the door to future targeted therapies.

01/08/2013 - 15:36

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurological disorder with few effective treatments and no known cure. The most frequent cause of death in ALS patients is breathing failure because, as the disease progresses, it kills the nerve cells that cause the respiratory muscle to contract.

06/13/2012 - 15:59

Studying how nerve cells send and receive messages, Johns Hopkins scientists have discovered new ways that genetic mutations can disrupt functions in neurons and lead to neurodegenerative disease, including amyotrophic lateral sclerosis (ALS).