Histone deacetylase inhibitors

01/16/2014 - 12:25

Memories of traumatic events often last a lifetime because they are so difficult to treat through behavioral approaches. A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

 

02/28/2012 - 14:57

A biochemical process of adding a methyl group in the DNA which can be inherited is DNA methylation. Histone deacetylase inhibitors such as sulforaphane present in cruciferous vegetalbes are investigated as possible treatments for cancer. Oregon State University study found that these epigenetic mechanisms play similar role in restoring balance and preventing cancer development.