05/01/2012 - 11:00

Scientists now demonstrate that a protein called Sirtuin 1 (SIRT1) is essential for the beneficial effects of resveratrol, a red wine ingredient. This important finding gives a new twist to a recent report from another group that suggested only an indirect relationship between resveratrol and SIRT1.

12/18/2011 - 23:12

Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders. In a report receiving advance online publication in Nature Medicine, a Massachusetts General Hospital (MGH)-based research team reports that increased expression of Sirt1, one of a family of enzymes called sirtuins, in the brain of a mouse model of HD protected against neurodegeneration. They also identified a potential mechanism for this protective effect.