beta cells

04/15/2014 - 21:25

A new study demonstrates very high plasma levels of a protein called islet amyloid polypeptide (IAPP) in type 1 diabetes patients of recent onset. The study was conducted on serum or plasma samples obtained from a nationwide Swedish prospective cohort study that recruits new-onset Type 1 diabetes children.

03/10/2014 - 16:24

Destruction of insulin-producing beta cells in the pancreas is at the heart of type 1 and type 2 diabetes. “We are looking for ways to make new beta cells for these patients to one day replace daily insulin injections,” says Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania. Transplanting islet cells to restore normal blood sugar levels in patients with severe type 1 diabetes is one approach to treating the disease, and using stem cells to create beta cells is another area of investigation. However, both of these strategies have limitations: transplantable islet cells are in short supply, and stem cell-based approaches have a long way to go before they reach the clinic.

 

01/22/2014 - 06:58

Two new studies led by UC San Francisco scientists shed new light on the nature of beta cells, the insulin-producing cells in the pancreas that are compromised in diabetes.

 

09/12/2013 - 13:40

Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 – a beta-cell enriched transcription factor – is essential to maintaining the functional state of beta cells. 

 

03/22/2012 - 22:07

Scientists have found that a specific type of cellular stress called ER stress takes place in pancreatic beta cells before the onset of type I diabetes (T1D), and that this stress response in the beta cells may facilitate the autoimmune attack. According to the authors, the results could help scientists identify and validate potential drug targets to alleviate ER stress and preserve beta cell mass in T1D

01/20/2012 - 12:51

During pregnancy, insulin-producing beta cells proliferate, or self-renew, to meet new metabolic demands. Pregnancy therefore represents a unique window for studying molecules involved in expanding beta cell mass, which could lead to novel therapies for patients with diabetes.