breast cancer

05/27/2014 - 10:01

A new drug targeting the protein PTP1B, which is up-regulated in HER2-positive breast cancer, has given positive results in reducing tumour growth and lung metastases in a mouse model of HER2-positive breast cancer. This is the major finding of a paper appearing online in the journal Nature Chemical Biology, from a multi-institution team led by Cold Spring Harbor Laboratory scientists.

 

04/09/2014 - 14:23

Scientists at the Salk Institute have uncovered details into a surprising—and crucial—link between brain development and a gene whose mutation is tied to breast and ovarian cancer. Aside from better understanding neurological damage associated in a small percentage of people susceptible to breast cancers, the new work also helps to better understand the evolution of the brain.

 

03/26/2014 - 10:47

Peach extract reduces lung metastases in a mouse model of breast cancer. The reduction is due to phenolic compounds in the peach extract and is mediated via reduction of expression of enzymes called metalloproteinases which are associated with cancer metastases. These are the results of an article in press in the Journal of Nutritional Biochemistry from researchers in Texas A&M University AgriLife Research.

 

03/25/2014 - 08:10

Like other areas of the body previously thought of as sterile, the female breast harbours a unique microbiome or population of bacteria. Both beneficial and pathogenic bacteria are present and there are preliminary indications that that the levels of E. coli may be higher in cancerous breasts. These are the main findings of a new study published ahead of print in Applied and Environmental Microbiology from researchers in Canada and Ireland.

 

02/11/2014 - 21:42

One of the most devastating developments that can occur in breast cancer is if the cancer metastasises to the brain. When this occurs prognosis is very poor due to the paucity of treatment options- limited to surgery and radiation- and fewer than two percent of these patients survive beyond two years. However, a new study dissecting the genetic markers that characterise breast cancer that spreads to the brain may offer new hope for future development of targeted small molecule drugs. The study, published in the scientific journal PLOS ONE, was led by scientists in the Translational Genomics Research Institute (TGen) in Phoenix, Arizona. Its purpose was to elucidate both common and rare events underlying metastases of breast cancer to the brain.

 

02/04/2014 - 12:13

According to the United States Centers for Disease Control and Prevention, breast cancer is the most common cancer in women. For patients whose breast cancers are hormone-dependent, current treatment focuses on using drugs that block estrogen (a type of hormone) from attaching to estrogen receptors on tumor cells to prevent the cells from growing and spreading.