cell nucleus

12/21/2012 - 15:48

Free-floating pieces of DNA in a cell’s watery interior can mean bad things: invading viruses, bacteria, or parasites, ruptured cellular membranes, or disease. Genetic material is meant to be contained in a cell’s nucleus or key organelles, and when it’s loose, it’s a sign for the immune system that something is wrong. Now, Howard Hughes Medical Institute scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus in the cytosol and setting off the resulting immune reaction.

10/10/2012 - 11:18

Scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory, with collaborators from Harvard University, the University of Madrid, Princeton University, and the University of Zurich, have discovered a new mechanism that may alter principle understandings of molecular interactions within a cell’s nucleus. The discovery illustrates how two proteins of the human adenovirus use DNA as an efficient form of transportation inside a newly synthesized virus particle. The proteins use what the scientists are calling a “molecular sled".

04/13/2012 - 22:22

Chloroplasts, the plant cell’s green solar power generators, were once living beings in their own right. This changed about one billion years ago, when they were swallowed up but not digested by larger cells. Since then, they have lost much of their autonomy. As time went on, most of their genetic information found its way into the cell nucleus; today, chloroplasts would no longer be able to live outside their host cell. Scientists in Ralph Bock’s team at the Max Planck Institute of Molecular Plant Physiology have discovered that chloroplast genes take a direct route to the cell nucleus, where they can be correctly read in spite of their architectural differences.

11/10/2011 - 22:55

Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in Wednesday's (Nov. 9) issue of the Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine say this process is even more complex than previously thought, with regulated genes actually relocated to other, more conducive places in the cell nucleus.

10/03/2011 - 09:51

Adenoviruses trigger respiratory problems and are dangerous to humans than previously thought. Porter molecules and manipulate them to penetrate through the host cell into the cell nucleus. A research team led by cell biologist and virologist at the University of Zurich was able to present evidence of this mechanism in detail.