epidermis

04/25/2014 - 07:37

Skin layer grown from human stem cells could replace animals in drug and cosmetics testing. An international team led by King’s College London and the San Francisco Veteran Affairs Medical Center (SFVAMC) has developed the first lab-grown epidermis – the outermost skin layer - with a functional permeability barrier akin to real skin.  The new epidermis, grown from human pluripotent stem cells, offers a cost-effective alternative lab model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.

07/05/2012 - 13:12

In the July 6 issue of Cell Stem Cell, researchers at the University of California, San Diego School of Medicine describe how human epidermal progenitor cells and stem cells control transcription factors to avoid premature differentiation, preserving their ability to produce new skin cells throughout life. The findings provide new insights into the role and importance of exosomes and their targeted gene transcripts, and may help point the way to new drugs or therapies for not just skin diseases, but other disorders in which stem and progenitor cell populations are affected.

05/26/2012 - 12:11

HER2 and its epidermal growth factor receptor cousins mobilize a specialized protein to activate a major player in cancer development and sugar metabolism, scientists report in the May 25 issue of Cell.