epigenetics

08/25/2014 - 19:00

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas – the primary form of a deadly brain cancer – are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.

 

04/09/2014 - 11:16

In a new study led by Soojin Yi at Georgia Institute of Technology points the role of DNA methylation in regulating duplicate genes. DNA methylation is addition of a methyl group to the DNA nucleotide cytosine or adenine and some of this is heritable. This study found that small methyl group attaches to the duplicate genes and prevent that gene from being active providing explanation to why duplicate genes are lost eventually.

 

03/07/2014 - 09:41

People with type 2 diabetes have epigenetic changes on their DNA that healthy individuals do not have. This has been shown in a major study by researchers at Lund University. The researchers also found epigenetic changes in a large number of genes that contribute to reduced insulin production.

 

02/17/2014 - 10:50

Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

 

02/05/2014 - 10:13

Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found a chemical “signature” in blood-forming stem cells that predicts whether patients with acute myeloid leukemia (AML) will respond to chemotherapy.

 

02/26/2013 - 11:13

Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health. By studying how HDAC activity, as well as other epigenetic regulators, controls lung development and regeneration, they hope to develop new therapies to alleviate the unmet needs of patients with asthma and COPD.