idiopathic CD4 lymphopenia

04/20/2012 - 14:22

Researchers at National Jewish Health have discovered a novel genetic mechanism of immune deficiency. Magdalena M. Gorska, MD, PhD, and Rafeul Alam, MD, PhD, identified a mutation in Unc119 that causes immunodeficiency  known as idiopathic CD4 lymphopenia.  Unc119 is a signaling protein that activates and induces T cell proliferation. The mutation impairs Unc119 ability to activate T cells.  Dr. Gorska, will present her findings April 20 at Translational Science 2012, an NIH-funded  conference in Washington D.C.