oncogene

05/13/2014 - 09:08

Whitehead Institute scientists have identified a genetic cause of a facial disorder known as hemifacial microsomia (HFM). The researchers find that duplication of the gene OTX2 induces HFM, the second-most common facial anomaly after cleft lip and palate.

 

01/24/2014 - 07:14

Oncogenes deregulate fundamental cellular functions, leading to the development of tumors and metastases. A recent study published in the scientific journal PNAS, by researchers at the Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet together with colleagues at The Royal Institute of Technology (KTH), clarifies how oncogenes induce the stiffness and invasive capacity of transformed cells.

 

09/19/2013 - 15:55

Mayo Clinic researchers have shown that a specific protein pair may be a successful prognostic biomarker for identifying smoking-related lung cancers. The protein — ASCL1 — is associated with increased expression of the RET oncogene, a particular cancer-causing gene called RET. The findings appear in the online issue of the journal Oncogene.

 

04/26/2012 - 12:44

Researchers at Dana-Farber Cancer Institute have shown that advanced pancreatic cancers in mice can't survive without continued expression of a mutant oncogene that "rewires" key metabolic pathways to fuel the cancer cells.