07/28/2014 - 10:14

As part of a multinational, collaborative effort, researchers from the Broad Institute, Massachusetts General Hospital (MGH), and scores of other institutions from all over the world have helped identify over 100 locations in the human genome associated with the risk of developing schizophrenia in what is the largest genomic study published on any psychiatric disorder to date. The findings, which are published online in Nature, point to biological mechanisms and pathways that may underlie schizophrenia, and could lead to new approaches to treating the disorder, which has seen little innovation in drug development in more than 60 years.


08/26/2013 - 10:28

Research on the underlying causes of schizophrenia are now taking a big leap forward, when scientists at Karolinska Institutet and colleagues in the United States have identified 13 new genetic variants that increase the risk for schizophrenia. The study, which is published in the scientific journal Nature Genetics, is based on blood samples from more than 59 000 individuals and provides the hitherto strongest clues to what causes schizophrenia.


01/07/2013 - 11:31

In September 2012, the Encyclopedia of DNA Elements (ENCODE) Project Consortium, a multi-institution collaboration that included the Broad Institute, capped off nine years of research with a flurry of papers that characterized proteins, enzymes, and other functional elements of the human genome. These elements, which were once dismissed as “junk DNA” because they were not among the protein-coding genes, are now thought to fulfill key functions, often regulating how and when genes are activated.

08/28/2012 - 13:45

People who carry a “G” instead of an “A” at a specific spot in the sequence of their genetic code have roughly a six-fold higher risk of developing certain types of brain tumors, according to a study by researchers at the University of California, San Francisco and Mayo Clinic.

05/01/2012 - 09:30

Fifteen of every 100 couples in the world who want to have children find it difficult or impossible to conceive. In about half those couples, the male partner is infertile. Now researchers at the University of North Carolina at Chapel Hill Nutrition Research Institute in Kannapolis have found a possible genetic cause for some cases of male infertility.