injury

08/11/2014 - 08:37

While neurons normally fail to regenerate after spinal cord injuries, neurons formed from human induced pluripotent stem cells (iPSCs) that were grafted into rats with such injuries displayed remarkable growth throughout the length of the animals’ central nervous system. What’s more, the iPSCs were derived from skin cells taken from an 86-year-old man. The results, described in the Cell Press journal Neuron, could open up new possibilities in stimulating neuron growth in humans with spinal cord injuries.

 

06/24/2014 - 20:52

In the complex environment of a spinal cord injury, researchers have found that immune cells in the central nervous system of elderly mice fail to activate an important signaling pathway, dramatically lowering chances for repair after injury.

11/08/2013 - 13:30

Researchers at Washington University School of Medicine in St. Louis have identified a chain reaction that triggers the regrowth of some damaged nerve cell branches, a discovery that one day may help improve treatments for nerve injuries that can cause loss of sensation or paralysis.

 

11/07/2013 - 15:49

Young animals recover from tissue damage better than adults, and from Charles Darwin's time until now, scientists have puzzled over why this is the case. A study published by Cell Press November 7th in the journal Cell has revealed that an evolutionarily conserved gene called Lin28a, which is very active in embryos but not in adults, enhances tissue repair after injury when reactivated in adult mice. The findings open up new avenues for the treatment of injuries and degenerative diseases in adult humans.

 

11/05/2013 - 11:00

Developing an efficient way to freeze and store living tissues could transform many aspects of medical care and research, but ice crystallization often occurs within cells during such cryopreservation procedures, leading to cell death. In the November 5 issue of the Biophysical Journal, a Cell Press publication, researchers report that they have gained new information about the processes that are responsible for promoting the freezing of cells within tissues. This knowledge may ultimately lead to novel approaches for preventing tissue injury during cryopreservation.

 

09/27/2013 - 09:24

Scientists at The Scripps Research Institute (TSRI) have discovered an important process by which special immune cells in the skin help heal wounds. They found that these skin-resident immune cells function as “first responders” to skin injuries in part by producing the molecule known as interleukin-17A (IL-17A), which wards off infection and promotes wound healing.